Vitamin B12, also known as cobalamin, is a powerhouse nutrient essential for maintaining overall health. It plays a crucial role in the formation of red blood cells, DNA synthesis, and the proper functioning of the nervous system.
Despite its importance, many people may not get enough B12 from their diets, especially those following vegetarian or vegan lifestyles.
The recommended dietary allowance for adults is 2.4 micrograms, but certain individuals, such as pregnant or nursing women, may require higher amounts.
Supplementing with vitamin B12 can offer a variety of health benefits, from enhancing cognitive function to promoting healthy skin and bones.
Understanding these benefits can empower individuals to make informed choices about their nutrition and overall well-being.

1. Supports Red Blood Cells and Prevents Anemia
Vitamin B12 plays a crucial role in producing red blood cells. Low levels of this vitamin can lead to decreased red blood cell formation and result in their improper development.
As a result, the cells become larger and oval-shaped, which makes it difficult for them to leave the bone marrow and enter the bloodstream smoothly.
This condition can cause megaloblastic anemia, where the body lacks sufficient red blood cells to deliver oxygen to vital organs effectively.
Symptoms of anemia may include fatigue and weakness, highlighting the importance of maintaining adequate vitamin B12 levels for overall health.
2. Prevents Birth Defects
Maintaining adequate vitamin B12 levels is vital during pregnancy to prevent birth defects. A deficiency in the early stages can significantly increase the risk of neural tube defects, which affect the brain and spinal cord.
Studies indicate that mothers with B12 levels below 250 milligrams per deciliter (mg/dL) are 2.5 to 3 times more likely to give birth to a child with such defects.
Furthermore, the risk escalates to five times higher for those with levels below 150 mg/dL. Consequently, ensuring sufficient vitamin B12 intake is crucial for the health of both the mother and the developing fetus.
3. Strengthens Bones and Prevents Osteoporosis
Vitamin B12 plays a key role in maintaining bone health. Research from 2021 indicates that low levels of vitamin B12 may link to poor bone density, increasing the risk of osteoporosis. Individuals with insufficient B12 could face fractures due to weakened bone structure.
Clinical studies generally do not support using B vitamins to prevent osteoporotic fractures, highlighting the need for further research. Ensuring adequate B12 intake might help keep bones strong and resilient over time.
4. Protects Against Macular Degeneration
Vitamin B12 plays a crucial role in reducing the risk of macular degeneration, an eye disease that affects central vision.
Studies have shown that a high intake of B vitamins is linked to lower rates of advanced age-related macular degeneration.
Individuals in research involving 5,000 women aged 40 and older demonstrated a 34% decrease in cases of macular degeneration after seven years when supplementing with vitamins B12, B6, and folic acid compared to a placebo group.
This suggests that B12 may help lower homocysteine levels in the bloodstream, contributing to vision health.
More research is needed, but B12’s promise for preventing visual decline highlights the importance of maintaining adequate levels for eye health.
5. Boosts Mood and Reduces Depression
Vitamin B12 plays a crucial role in boosting mood and potentially reducing symptoms of depression.
Research indicates that B12 is necessary for the production of neurotransmitters like serotonin and dopamine, which are vital for mood regulation.
Low levels of B12 have been linked to a 51% increased risk of developing depression, especially in older adults over four years.
Studies show B12 supplementation can improve depressive symptoms and enhance the effectiveness of antidepressant medications.
While some research has not definitively proven B12’s influence on depression, it consistently highlights the connection between low B12 levels and a greater risk of depressive symptoms.
6. Enhances Brain and Memory
Vitamin B12 plays a critical role in supporting brain function. It’s been linked to reduced memory loss, particularly in older adults experiencing cognitive decline.
Research shows that individuals with early-stage dementia might benefit from B12, especially those with higher omega-3 fatty acid levels.
Even levels of B12 that are on the low side of normal can negatively impact memory performance, emphasizing its importance. Ongoing studies aim to explore these connections in larger groups to establish more definitive findings.
7. Improves Energy Levels
Vitamin B12 plays a crucial role in energy production within the body. Individuals with vitamin B12 deficiency often report feelings of fatigue and low energy. Addressing this deficiency can lead to a significant improvement in energy levels.
Research notes that supplementation may help those deficient in B12 to regain their lost vitality. Nevertheless, simply taking B12 supplements won’t automatically boost energy for those without a deficiency.
Studies emphasize that B12’s actual contribution to energy lies in its vital functions, rather than providing energy directly. Thus, maintaining adequate B12 levels is essential for overall energy health.
8. Promotes Healthy Hair, Skin, and Nails
Vitamin B12 plays a significant role in maintaining healthy hair, skin, and nails. Deficiencies in B12 can lead to noticeable complications like hyperpigmentation or nail discoloration.
Furthermore, individuals may experience hair changes or even patchy skin color from conditions associated with low B12 levels.
Canker sores, also known as aphthous stomatitis, can emerge in the mouth, which may further indicate a B12 deficiency. It’s crucial to have adequate B12 for supporting the health of these essential features.
While research indicates that people without a deficiency may not benefit from additional B12 supplementation, maintaining proper levels remains vital for overall skin, hair, and nail health.
Who Are at Risk of Vitamin B12 Deficiency?
Individuals following vegetarian or vegan diets often lack sufficient vitamin B12, as it’s primarily found in animal products.
Older Adults
Older adults often face increased risks of vitamin B12 deficiency due to factors like reduced absorption in the digestive system.
They may experience lower stomach acid production, which affects B12 absorption from food sources. Regular checks for B12 levels can be vital for this age group, as deficiency can lead to serious health issues.
People With Gastrointestinal Disorders
Individuals with gastrointestinal disorders often face challenges in absorbing vitamin B12 adequately. Conditions like Crohn’s disease and celiac disease can impair the body’s ability to absorb nutrients, including B12.
Many people with these disorders may develop deficiencies, leading to symptoms like fatigue and neurological issues.
Individuals With Gastrointestinal Surgeries
Individuals who’ve had gastrointestinal surgeries, like gastrectomy or gastric bypass, may experience significant challenges with vitamin B12 absorption.
Such surgical procedures often result in reduced production of hydrochloric acid and intrinsic factor, crucial for B12 uptake.
Strict Vegans
Strict vegans often struggle to get enough vitamin B12, as this essential nutrient is primarily found in animal products.
They should consider fortified foods, like plant milks, breakfast cereals, and nutritional yeast, which can help boost B12 intake.
Regularly checking B12 levels is crucial for preventing deficiencies, especially in strict vegan diets.
Metformin Users
Metformin can significantly impact vitamin B12 levels. Research shows that long-term use of metformin is linked to decreased serum B12 levels in individuals with type 2 diabetes.
Approximately 10% to 30% of metformin users experience vitamin B12 deficiency, which often goes unnoticed.
Proton Pump Inhibitor Users
Proton pump inhibitors (PPIs) can adversely affect vitamin B12 levels. Research indicates that long-term PPI use is linked to vitamin B12 deficiency.
It’s estimated that this deficiency affects 12% to 35% of individuals on PPIs. Individuals using these medications should be aware of their risk for a decrease in B12 levels.
